ObjectiveTo study the clinical efficacy and safety of radiofrequency catheter ablation for atrial fibrillation (AF) by domestic minimally invasive Columbus^® system.MethodsA total of 26 patients with AF who had undergone radiofrequency catheter ablation with Columbus^® system and its supporting catheter were successively selected. The immediate success rate of surgery, intraoperative related parameters and surgery-related complications were recorded, while the recurrence of AF and the occurrence of adverse events were observed during follow-up.ResultsThe enrolled 26 patients were all paroxysmal AF. Pulmonary vein isolation was successfully achieved during operation, and there were no complications related to radiofrequency catheter ablation during perioperative period. During a mean follow-up of (5.92±1.94) months, AF recurred in 5 of 26 patients(19.23%). No serious adverse events such as embolism, bleeding, atrial esophageal fistula, or death occurred during the follow-up.ConclusionRadiofrequency catheter ablation for AF by using domestic minimally invasive Columbus^® system is clinically feasible, with satisfactory short-term efficacy and safety.