Journal of Innovative Optical Health Sciences, Volume. 16, Issue 3, 2330003(2023)

Recent advances in Raman spectroscopy for skin diagnosis

Min Wu1、*, Beibei Gao2, and Xunbin Wei3,4,5
Author Affiliations
  • 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P. R. China
  • 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China
  • 3Institute of Medical Technology, Peking University, Beijing 100181, P. R. China
  • 4Biomedical Engineering Department, Peking University, Beijing 100081, P. R. China
  • 5International Cancer Institute, Peking University, Beijing 100191, P. R. China
  • show less

    The skin is the largest organ in humans. It comprises about 16% of our body. Many diseases originate from the skin, including acne vulgaris, skin cancer, fungal skin disease, etc. As a common skin cancer in China, melanoma alone grows at year rate of nearly 4%. Therefore, it is crucial to develop an objective, reliable, accurate, non-invasive, and easy-to-use diagnostic method for skin diseases to support clinical decision-making. Raman spectroscopy is a highly specific imaging technique, which is sensitive, even to the single-cell level in skin diagnosis. Raman spectroscopy provides a pattern of signals with narrow bandwidths, making it a common and essential tool for researching individual characteristics of skin cells. Raman spectroscopy already has a number of clinical applications, including in thyroid, cervical and colorectal cancer. This review will introduce the advantages and recent developments in Raman spectroscopy, before focusing on the advances in skin diagnosis, including the advantages, methods, results, analysis, and notifications. Finally, we discuss the current limitations and future progress of Raman spectroscopy in the context of skin diagnosis.


    Get Citation

    Copy Citation Text

    Min Wu, Beibei Gao, Xunbin Wei. Recent advances in Raman spectroscopy for skin diagnosis[J]. Journal of Innovative Optical Health Sciences, 2023, 16(3): 2330003

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category: Research Articles

    Received: Jul. 23, 2022

    Accepted: Jan. 11, 2023

    Published Online: May. 25, 2023

    The Author Email:



    Please enter the answer below before you can view the full text.