Chaboche′s model of nonlinear continuum fatigue damage is modified based on the impact of crack closure and residual tension stress of laser cladding effect on fatigue damage. A cumulative fatigue damage model is developed accordingly to predict the fatigue life for laser cladding component. The related parameters are concluded from fully reversed fatigue experiment and static tension test and residual tension stress test. To verify the proposed model, tension-compression fatigue tests under two stage loadings (high-low loading and low-high loading) are carried out. The results show that the calculated value and experimental value are in good agreement. It has been proved to be an efficient method to predict the fatigue life of the laser cladding component.