Three sets of GH4169 samples were formed by selective laser melting technology using optimized process parameters, and high temperature fatigue test specimens were prepared. The porosity of the fatigue test specimens were measured by industrial CT, and the fatigue cycle tests were carried out at 650 ℃. The fracture morphology of the fatigue specimens was observed by SEM and the fracture mechanism was analyzed. The results show that some parameter sets pecimens have micropores of about 100 μm, which have no effects on fatigue fracture through subsequent analysis. The fatigue cycle number of the three sets samples do not change significantly with the change of process parameters, and all of them could reach 105~107 cycles, but the fatigue properties are lower than that of the forging part under the same test condition. The fracture morphology shows that the crack sources of are located on the surface of the specimens, and both brittle fracture and plastic fracture coexist in the process.