To effectively solve the problem of strong electromagnetic pulse power required to drive particle reactions, a new pulse power synchronous amplification technology based on hydrogen plasma loading and wave-particle resonance mechanism is studied on the basis of piezoelectric ceramic stack pulse source. The amplification mechanism is as follows: first, the energy of hydrogen molecule bonding orbitals is lower than that of antibonding orbitals, and internal energy will be released during the ionization process to promote the efficient occurrence of the ionization process driven by pulse power; Second, after the ionization of hydrogen atoms, the electromagnetic field and electrons undergo wave-particle resonance, and the electron energy is synchronously converted into electromagnetic field energy. After the amplification of wave-particle resonance, a stronger electromagnetic pulse is obtained, which can form a spherical electromagnetic field when applied to the spiral electrode, and has an extremely high acceleration gradient, which can accelerate a large number of protons produced after efficient ionization of hydrogen atoms. The above theory is effectively proved through experimental tests and simulation analysis, and this research is expected to lay a foundation for a miniaturized and low-cost proton generator driven by strong electromagnetic pulses.