Based on the investigation, the Yongzhou Vocational and Technical College Bright Eyes Public Welfare Association conducted an in-depth analysis of the major factors influencing adolescent myopia from the perspectives of genetics, environment, and eye usage behaviors. It proposed to establish a four-level linkage of "city-district-community-school" collaborative work mechanism mode with multiple departments in the field of "medical-education-physical training", a multi-dimensional health promotion mechanism of "behavior-environment-diet" and a multi-field comprehensive treatment system of "light-drug-therapy" to comprehensively prevent and control adolescent myopia. Through practice, the comprehensive intervention strategy for adolescent myopia in Yongzhou region achieved initial results, providing scientific basis and practical guidance for the prevention and control of adolescent myopia in other regions.