Patients with moderate myopia were divided into group A(?3.00 D≤subjective sphericity ≤?4.00 D) and group B(?4.00 D0.05), and there was a significant decrease compared to the baseline period (P<0.05). The amount of change in group B was higher than that in group A (P<0.05). Wearing NOR aspherical OK lenses in patients with moderate myopia can effectively improve UCDVA, reduce refractive power, and do not affect intraocular pressure and corneal endothelial cells. The lens matching is really high, with fewer complications, and it is safe and reliable to use in conjunction with hydrogen peroxide care solution.