Au-ITO-Ag symmetry-breaking multilayered nanoshells dimer were systematically investigated by near field enhancement characteristics based on the finite element method. The localized surface plasmon resonance properties are explained by the plasmon hybridization theory. The results show that the plasmon resonance peak of the symmetry-breaking multilayered nanoshells dimer is very sensitive to the change of the radius of the Au core. The electric field of the symmetry-breaking multilayered nanoshells dimer is mainly distributed on the surface of the nanoshells dimer, and the electric field intensity is most prominent in the Ag nanocup opening part, whose highly adjustable optical properties provide a solid theoretical basis for improving biosensor technology.