The CoCrFeNiMo/SiC high entropy alloy coating with SiC particles was prepared by laser cladding with 45Cr steel for internal combustion engine. The differences and influencing factors in microstructure, mechanical properties and wear resistance between the first CoCrFeNiMo (S1), the second CoCrFeNiMo and 10%SiC (S2), the third CoCrFeNiMo and 20%SiC (S3) were compared and analyzed. Results showed that in addition to FCC phase structure, M7C3 components (M stands for Cr, Mn, Fe) were detected in S2 and S3 samples. There is a circular arc structure between S1 coating and substrate. The longitudinal section of S2 coating forms a good bonding state. The second sublayer with smaller thickness was formed in S3 coating, and the coating dilution rate increased. After adding SiC into the sublayer, the brittle and hard M7C3 products were formed, which showed higher hardness. Obvious abrasive wear occurred after S1 coating wear. The surface area of S2 coating formed deeper wear marks and a large amount of shedding occurred. S3 coating formed more large size precipitates, which showed the characteristics of abrasive wear.