With the rapid development of stereoscopic display technology, integral imaging three-dimensional (3D) display technology has been widely researched. But the visual crosstalk in integral imaging seriously affects its stereoscopic visual effect. In order to reduce the crosstalk and improve the visual comfort, a crosstalk-free integral imaging 3D display based on a mask array was proposed. The mask array was particularly designed to block the light from the adjacent elemental images. The proposed structure can effectively eliminate the crosstalk caused by the adjacent elemental images, and it is compact and easy to be fabricated. In this paper, the distribution of viewing area and the viewing angle of integral imaging were analyzed, and the design principle and structure of the proposal were described in detail. The experimental results show that the proposed structure can completely block the crosstalk caused by the adjacent elemental images and effectively reduce the crosstalk in integral imaging. As the viewing angle increasing, the crosstalk image was gradually blocked and eventually disappeared, the 3D visual effect was improved.