Aiming at the laser cleaning of petrochemical equipment, firstly, the laser cleaning process for black skin of stainless steel weldment is studied by building a process platform, and the process parameters of the best cleaning effect and the most efficient cleaning process were obtained. Secondly, tensile and bending test of the stainless steel weldment with excessive laser cleaning, normal laser cleaning and without cleaning were carried out. The ultimate tensile strength of the stainless steel weldment with excessive laser cleaning exceeded the value in the standard by 17.3%, and no cracks were found on the surface of the welding area and the heat affected zone in the bending test, which means that all specimens are accord with NB/T47016-2011 “Mechanical property tests of product welded test coupons for pressure equipment”. It is proved that static strength mechanical properties of welding area of petrochemical equipment with laser cleaning meets the engineering requirements, indicating that laser cleaning is a safe cleaning method. Finally, through the situ laser cleaning test, the cleaning effect and cleaning efficiency is considered, and the advantages of selective laser cleaning, small damage and good accessibility are also taken into account, the recommended level of laser cleaning on various occasions of petrochemical equipment is proposed, which provides a reference for the application of laser cleaning technology in the petrochemical field.