Objective: To study the treatment effect on herpes zoster with He-Ne laser. Methods: 245 cases of herpes zoster were divided into two groups according whether using He-Ne laser or not , and +hey were analyzed from the days of crusts forming, exuviating and pain disappearing. Results: He-Ne laser can be effectually used in herpes zoster, it may help to make the crusts generating, falling cut and ache going away, which can reduce the days of illness.