Due to high hardness and corrosion resistance, the Mo2NiB2 ternary boride could be used in the surface protection engineering of Q235 steel. In this work, Mo, Ni, B powders were used as raw materials to in-situ fabricate the Mo2NiB2based cermet coatings on Q235 substrate by the laser cladding technology. The influence of laser cladding times on the structure and property of the coatings was investigated. The results showed that the laser-cladded Mo2NiB2coatingwas composed of Mo2NiB2 ceramic hard phase and FeNi alloy bonding phase. With increasing the times of laser cladding, the relative content of Mo2NiB2 ceramic phases firstly increased and then decreased. The Mo2NiB2 ceramic phase tended to aggregate in the middle sites of thecoatings. Besides, a metallurgical bonding zone with a gradient of composition was formed between the cladding Mo2NiB2 coating and the Q235 substrate. As the laser cladding times increased, both the hardness and corrosion resistance of the Mo2NiB2coating were firstly enhanced and then weakened. Especially, the highest hardness and corrosion resistance of the coatings were obtained when the laser cladding by 3 times, which were 1 and 2 orders of magnitude higher than Q235 substrate, respectively. The changes in the properties of the Mo2NiB2coatingswere mainly determined by the microstructure and relative content of the ceramic phase in coatings.