Objective; To observe the clinical Effect of patients with upper gastrointestional polyp Treated by Ho: YAG Laser. Methods; 106patients with upper gastrointestionsl polyp were treated by Ho:YAG laser through endoscope . Results; Of the 106 case, the cure rates of esophageal polyp was 93% , cardiac polyp 80% , gastric polyp 98% ,duodenal polyp 100%. Conclusion; The advantages of treatment by Ho; YAG laser in upper gastrointestinal polyp was simple, less pain, safty, mild postoperative reaction.