The influence of optical breakdown on stimulated Brillouin scattering (SBS) process is investigated with purified CCl4, acetone, and CS2 mediums which are obtained through 0.22-μm pore-size filter. Experiments are conducted with a Nd:YAG Q-switched laser system. The optical breakdown threshold, the reflectivity and the stability of SBS in both purified and unpurified mediums are determined and compared. The improvement of optical breakdown threshold is observed more or less in all purified mediums. In the condition that optical breakdown does not occur after the medium purified, the energy reflectivity and the stability of SBS both show improvement. Therefore, the characteristics of SBS can be improved by purifying the mediums to obtain higher optical breakdown threshold which reduces the influence of optical breakdown on SBS process.