Based on the computer aided design (CAD) digital base of complete denture model, a titanium base was made with the RS-850 laser rapid forming system, which processing parameters were suitable. The method made the Ti-base faster comparing with the traditional one, and the shape of the complete denture base was very well. The success development of the titanium base provided a new method for the automatic manufacture of titanium prosthetic replacement, and would make the foundation for the clinical application in the future.