In order to solve the problem of flexible encapsulation of fiber Bragg grating (FBG) sensor, a FBG sensor with flexible resin as encapsulation layer was designed. Firstly, the impact of flexible resin encapsulation was analyzed. Secondly, the sensors encapsulated with flexible resin, polydimethylsiloxane, silicone were fabricated, and the pressure conditions of the sensors were analyzed by using Ansys software. Finally, the load, temperature sensitivity and static performance of the fabricated flexible sensor were compared with the bare FBG. The experimental results show that the FBG sensor encapsulated with flexible resin has good response and sensing ability. The average sensitivity of load is 4.644 pm/N, the average sensitivity of temperature is 1.685 pm/℃, and the goodness of fit of sensitivity is above 99.8%. The repeatability is 0.008, the hysteresis is 0.019, and the linearity is 0.01, which are better than the polydimethylsiloxane, silicone encapsulated FBG sensor and bare FBG. The research can provide reference for flexible encapsulation of FBG.