A LD side-pumped, high-energy, high-beam-quality, Q-switched all-solid-state Nd:YAG laser without water cooling is developed. The laser is integrally cooled by using a thermoelectric cooler (TEC), which is conducive to the miniaturization and portability of laser. The dimension of Nd:YAG crystal rod used in experiment is φ7 mm×100 mm and the Nd atom number fraction is 1.1%. The maximum peak power of LD pumping is 15 kW. The laser output at 1064 nm with the maximum pulse energy of 350 mJ, pulse width of 9.7 ns, optical-electrical conversion efficiency of 6.7% and energy stability less than 5% is obtained at 10 Hz repeat frequency. The beam qualities M² of horizontal and vertical directions are 7.7 and 12.3, respectively.