APPLIED LASER, Volume. 45, Issue 3, 177(2025)
Effects of Intranasal Photobiomodulation Therapy on Hepatic Fat Fraction in Patients with Hyperlipidemia
Objective:To evaluate the effects of intranasal photobiomodulation therapy (PBMT) on blood lipids and hepatic fat fraction in patients with hyperlipidemia.Methods:Twenty-two patients with hyperlipidemia were randomized into PBMT group and control group. PBMT group received intranasal 650 nm 10 Hz 10 mW/cm2 PBMT for 30 minutes once a day for consecutive 28 days. The control group received placebo-controlled treatment. All patients underwent three hepatic MRI IDEAL-IQ scans pre-treatment, the 14th day post-and the 28th day post-treatment to obtain hepatic fat fraction. Blood lipids profiles of two groups were collected pre-and the 28th day post-treatment. P<0.05 was considered statistically significant.Results:ANOVA showed significant systemic bias between FFpre, FF14days and FF28days in PBMT group (P<0.05) but no significant changes in control group. Tukey post-test showed that FF28days have significant changes compared with both FFpre and FF14days in PBMT group (P<0.05). However, FF14days had no significant change compared with FFpre. Paired T-test results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-c) and low density lipoprotein (LDL-c) in PBMT group were significantly changed between pre-and post-PBMT (P<0.05), however there was no significant difference in control group.Conclusion:Long-term and repeated application of 650 nm 10 Hz 10 mW/cm2 intranasal PBMT can reduce blood lipids and hepatic fat fraction in patients with hyperlipidemia, and prevent the occurrence of liver diseases.
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Ma Hui, Zhao Yu, Li Fengtan. Effects of Intranasal Photobiomodulation Therapy on Hepatic Fat Fraction in Patients with Hyperlipidemia[J]. APPLIED LASER, 2025, 45(3): 177
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Received: Apr. 27, 2023
Accepted: Jun. 17, 2025
Published Online: Jun. 17, 2025
The Author Email: Fengtan Li (left9999@sina.com)