Laser Net Shape Manufacturing (LNSM) of Ti-6Al-4V was investigated. The experiments were carried out in open air with shielding argon gas to prevent the materials from oxidation during laser deposition. It was discovered that power mass ratio (PV/Dm) was a key factor, which influenced both surface finish and microstructure of laser deposited parts. High value of power mass ratio will lead to a deposit with good surface quality and large columnar grain growth. The microstructure analysis showed that it consisted of very fine acicular α and β phases, and very dense metallurgical bonding was obtained. The Ti-6Al-4V components with good surface quality were fabricated through processing parameters optimized, in additional, the content of N and O elements introduced during deposition was very low, which indicated LNSM could fabricate the Ti-6Al-4V components with satisfactory quality in open air.