For field-to-line coupling problems, the classical transmission line theory is not applicable to obtain voltage/current responses on transmission lines irradiated by high-frequency electromagnetic disturbances. To solve this problem, a time-domain full-wave modeling method based on antenna theory and analog behavior modeling (ABM) is proposed. The Harrington method of moment is utilized to discretize the current integral equation and derive time-domain expression of the macromodel. Then, the inverse Fourier transform and time-domain convolution of the frequency-dependent parameters in the expression are realized by frequency domain function module (FREQ) of ABM. With embedding into the circuit solver, the model can directly solve the responses of high-frequency electromagnetic disturbances coupling to transmission lines with different structures above lossy ground. Compared with the traditional full-wave algorithms, the model can be applied to any circumstances of incident field and linear/nonlinear loads, and there is no need to solve the current integral equation repeatedly with time-consuming methods. The proposed method can simplify the process of the full-wave algorithm and improve the efficiency of simulation calculation. It is especially convenient to obtain statistical characteristics by performing efficient repeated simulations when the incident field and load are with uncertain parameters. Finally, taking the high frequency electromagnetic field coupling to two-conductor transmission lines above lossy ground as an example, the validity of the proposed macromodel and the limitation of the transmission line theory are verified by comparing the results with those of numerical electromagnetic code and traditional transmission line theory method. The results reveal that the macromodel based on the full-wave method can efficiently and accurately acquire the transient responses on transmission lines with any structure irradiated by high frequency electromagnetic disturbances in the time domain.