The traditional cloisonne enamel painting is mainly made by hand with a slow-speed draming, and the artistic effect of the painting will be affected if the quality is low. The laser processing technology has the characteristics of high precision, fast speed and high level of automation, and can be used in the production of cloisonne enamel painting. In this paper, the application of the laser processing technology in the production of cloisonne enamel painting is studied. Taking Wu Bing’s silk color painting “Hibiscus of Water” as an example, the process of manufacturing cloisonne enamel painting board using laser processing from design, debugging and processing to parameter setting is elaborated in detail, which provides ideas and references for the personalized customization and mass production of cloisonne enamel painting crafts in the future.