Chinese Journal of Lasers, Volume. 37, Issue 11, 2719(2010)
Upconversion Fluorescence Monitoring Near-Infrared During Tumor Photothermal Therapy
The photothermal therapy which mainly uses near-infrared laser to heat tissue has become a new validated method for tumor treatment through direct surface irradiating or inserting light fibers in tumor. The near-infrared light transfer in tissue is limit and the thermal effect occurs only in a small volume during treatment. Thus the treating extent is difficult to control. Otherwise, it is difficult to distinguish the boundary of tumor and normal tissue in photothermal therapy. Improper heating will hurt the normal tissue. So it is important to guide the laser in time in thermal therapy. The results indicate that by using upconversion nanoparticles[Yb/Er (NaYF4Yb, Er)] to localize on tumor, the infrared light can be monitored in real time with the upconversion fluorescence. The light dosage, distribution, heating extent and the boundary of tumor can be detected to increase the effect of thermal therapy.
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Wei Yanchun, Wu Baoyan, Yang Liyong, Xing Da. Upconversion Fluorescence Monitoring Near-Infrared During Tumor Photothermal Therapy[J]. Chinese Journal of Lasers, 2010, 37(11): 2719
Category: biomedical photonics and laser medicine
Received: Jun. 12, 2010
Accepted: --
Published Online: Nov. 16, 2010
The Author Email: Wei Yanchun (weiyanchun@scnu.edu.cn)