Aiming at the problems of easy deformation, complicated debugging and inconvenient operation the laser drilling process for the soft micro-spray belt with the thickness of 1.2 mm or less, a set of micro-spray belt laser drilling positioning fixture with high flexibility and versatility is designed. The fixture is primarily composed of a support mechanism, a centering mechanism and an anti-penetration mechanism. Through experimental improvement, it can ensure the precise positioning and alignment of the micro-spray belt with the bandwidth within 100 mm, and realize the dynamic continuous precision drilling of the micro-spray belt with a dynamic on-line speed of 57 m/min, which achieves the expected production effect and is suitable for the industrialization development requirements of the micro-spay belt, and serve as a reference for the processing fixtures design of the same type of parts.