The hard particles reinforced intermetallic composite coating was fabricated on biomedical TC4 titanium alloy by laser cladding process in this paper. The microstructure, phase structure and composition, distribution of hardness and corrosion resistance of the hard particles reinforced intermetallic composite coating were analysed by optical microscopy(OM), scan electron microscopy (SEM), Energy spectrum (EDS) quantitative analysis, X-ray diffraction (XRD) and polarization curve. The results show that the coating thickness up to 1~2 mm, and sufficiently dense, uniform, crack-free, and without porosity defects, the phase compositions of the coating including hard particles additonal B4C、in-situ synthesis TiB、TiB2 and TiC、TiNi/Ti2Ni dual phase intermetallic composite. The hardness of hard particles reinforced intermetallic composite coating is HV 0.3 899, nearly 3 times of the substrate, and the corrosion resistance of the coating is nearly 3 times of the substrate.