Tacking the research of glass lenses as reference, a statistical data-based index of liquid lens zoom stability and liquid lens repeated zoom accuracy is proposed. An experimental method is presented to optimize the structural parameters and materials of the liquid lens. Firstly, the main factors affecting the accuracy of a liquid lens’ repeat zoom accuracy were obtained through preliminary experimental research, including the polar solution volume, taper and non-polar solution viscosity. Secondly, taking the accuracy of the liquid lens’s repeat zoom accuracy and zoom range as evaluation indicators, it was found that the relationship between the accuracy of the liquid lens’s repeat zoom and the voltage is not monotonic, and that it rises first and then falls. On this basis, through the range analysis and comprehensive balance method, the primary and secondary factors and the optimal combination of parameters is obtained. After that, orthogonal experiments were used to optimize the design parameters. Finally, the effectiveness of this method was verified by experiments. The experimental results show that the repeat zoom accuracy of the optimized liquid lens is 0.2 m^-1, and the zoom range is -15.2-5.85 m^-1 over the voltage range of 0 to 230 V. It basically meets the requirements of stable and reliable, high precision, and large zoom range for liquid lens zoom.