In order to store, share, apply and mine more valuable information for residents' health, this paper designs a Hadoop-based regional health big data platform. The platform stored health data from various health institutions and physical examination institutions in the pre-database through data collection. The medical data was stored in the standard library through data governance and data exchange, and data was opened out in the form of data services to provide health big data support to medical institutions, physical examination institutions, health management companies, etc., which promoted the development of medical health products research and development, and better provided residents with medical and health services, and ultimately achieved full life cycle health data management.