To investigate the expression of phospholipase A2 groupⅦ (PLA2G7) gene in cervical cancer tissues by multiple tumor databases and bioinformatics methods, and to analyze the relationship between PLA2G7 and clinical prognosis and immune infiltration, we analyzed the genetic aberration, expression of PLA2G7 gene and its relationship with patient prognosis by using cBioPortal, GEO, GEPIA2, and TCGA databases. GSEA and GSVA were performed to evaluate the potential biological functions of PLA2G7. The correlations between PLA2G7 gene expression and immune infiltration and their marker genes were investigated via TIMER database. The results have indicated that compared with normal cervical tissues, PLA2G7 was higher in cervical cancer tissues, and high PLA2G7 expression were significantly enriched in immune-related pathways such as chemokine signaling pathway, natural killer cell-mediated cytotoxicity and T cell receptor signaling pathway. High expression of PLA2G7 was associated with prolonged OS (Log-rank P=0.030). Subgroup analysis revealed that high expression of PLA2G7 was related with better OS in older, stageⅠ&stageⅡ, and G3&G4 patients but not other subgroup patients. PLA2G7 expression was positively correlated with infiltrating levels of CD4+ T cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells. And it was strongly correlated with immune cell markers CD86, CD115 (CSF1R), CD163, MS4A4A, CD11c (ITGAX), CTLA4 and TIM-3 (HAVCR2). The results of analysis showed that in cervical tumor tissues, the high expression of PLA2G7 may improve the survival of patients by enhancing the recruitment signaling pathway of immune cells and regulating the enrichment of immune infiltration cells, which provides a theoretical basis for the use of PLA2G7 as a biomarker for the diagnosis and treatment of cervical cancer and its prognostic assessment.