Based on the influence functions of the deformable mirrors (DMs), the wavefront correction process is simulated by the finite element method and the influence of the fatigue characteristics of piezoelectric ceramics (PZT) actuators on the correction ability of DMs is analyzed. The research results show that the correction ability of DMs decreases when the phenomenon of the fatigue occurs in PZT actuators. The larger the peak-valley value of the distorted wavefront to be corrected or the higher the proportion of the spatial high-frequency components is, the more obvious of the decrease of the correction ability of DMs after the occurrence of fatigue is. In addition, the influence from the former is relatively larger.