In order to prepare lightweight high entropy alloy (LHEA) with suitable microstructure and excellent properties, Ti₃V₂NbAl_xNi_yLHEA with different Al and Ni ratios were prepared on TC4 substrate using laser cladding technology. Its microstructure, friction, and wear properties were studied, and the effect of adding a small amount of MoB ceramic particles on its microstructure and properties was discussed. The results show that the phases of Ti₃V₂NbAl_0.5Ni_0.5, Ti₃V₂NbAl_0.5 and Ti₃V₂NbNi_0.5 coatings are composed of a single body-centered cubic crystal（BCC）, while the second phase A15 is formed in Ti₃V₂NbAl_0.5Ni_0.5/MoB coatings. Compared with the hardness of the matrix, the hardness of four coatings has been improved. The wear forms of four coatings are mainly adhesive wear, with adhesive layer and a small amount of oxide layer distributed in the wear marks, and furrow characteristics caused by slight abrasive wear are also observed in the wear marks. Compared with the matrix, the wear rate of Ti₃V₂NbAl_0.5Ni_0.5/MoB coating is greatly reduced, and the wear rate of Ti₃V₂NbAl_0.5Ni_0.5/MoB coating is reduced by 51.1%. The LHEA in this paper has good wear resistance and can be used as a protective coating for TC4 parts in aerospace, national defense equipment manufacturing and other fields.