Sensors based on surface plasmon resonance (SPR) are widely recognized as valuable tools for sensing of liquid phase samples. It can be used in real-time monitoring of various biomolecular interactions, such as DNA hybridization and protein bindings since it is a simple, direct, real time and sensitive optical sensing technique used for probing refractive index changes. In recent years, Graphene (GR) has been applied in SPR sensors to improve the sensitivity. However, the detection sensitivity and accuracy of the sensors are lower for the loss of the electromagnetic field in GR which leads to the damping field and broad resonance peak in the SPR curve.