Fluorescence spectrum of transplanted tumour (mammary cancer), normal skin and gastric mucosa injected with AlSPc plus excited by dye laser (λ=607 nm) were studied in 18 mice. The main fluorescence peak of the tumour tissues spectra are located at about 681.9 nm, whereas this peak of normal skin are located around 682.7 nm, and the grastric muoosa are at 682.2 nm. The fluorescence intensity of the tumour than normal akin is 7.5:1 and the fluorescence intensity of the tumour than normal grastric mucosa. It has demonstrated selective localization and retention of AlSPc in cancerous tissues and SlSPc was less cytotoxic to cells. It may become a new potential photosensitizer in PDT of cancers.