The effect of laser process parameters on the cleaning quality of the surface paint of T300 carbon fiber was studied, and a CO2 laser was used to perform laser cleaning tests on the samples. The shape measuring laser microscope was used to measure the surface roughness and removal thickness of the sample after laser cleaning. The influence under different average laser power, overlap ratio and scanning times was studied. Through mechanical property analysis, paint adhesion test, aging test, temperature test and metallographic test, the results show that: the overlap rate of the laser average power and the spot is too large, which will cause certain damage to the carbon fiber surface. When the average laser power P=40 W, the spot overlap rate δ=65%, and the number of scans t=1, good laser cleaning quality can be achieved without affecting the mechanical properties of the material. The cleaned surface can meet the quality requirements of subsequent repainting. The research can provide technical reference for the engineering application of laser cleaning CFRP in aircraft manufacturing field.