In order to solve the problem of insufficient basis for fire protection design of the stilt floors in terminal buildings, this paper analyzes the fire protection characteristics of such stilt floors of the terminal buildings, and studies the fire smoke spread features in terminal stilt floors by the numerical simulation method. The results show that with the same height of stilt floor, the higher the fire power, the lower the height of smoke layer, and the greater the impact on personnel evacuation. The height of the smoke layer increases with the increase of the net height of the stilt floor. When the height of the stilt floor reaches 8m, the obvious smoke accumulation and settlement begins to occur at 30m horizontal distance from the fire source. The smoke layer height can be significantly improved by optimizing the smoke exhaust in the area with a depth greater than 30m. Combined with the smoke spreading characteristics of stilt floors, the fire separation strategies of ensuring the evacuation safety of the stilt floor are raised from the aspects of limiting fire load, conducting necessary fire separation, and reasonably configuring fire protection facilities, providing a reference for fire protection design of terminal buildings.