To realize the large area preparation and practical application of TiAl alloy coating on the surface of TC4 titanium alloy, a single and overlapped TiAl alloy coating was prepared on the titanium substrate by laser cladding. The cladding quality of the coating was analyzed by surface morphology and interface characteristics, the phase composition and microstructure of the coating were studied, and the hardness distribution between the interface of the cladding layer and the lap layer was measured. The results show that the coating is metallurgical, and there is no cracks and pores in the coating. The Ti/Al mainly exists in the form of TiAl(γ), Ti3Al(α2), and trace elements, and the coating is mainly composed of double-state structure and lamellar structure. The average hardness of single cladding coating and lap coating is more than 1.44 times that of substrate. The coating can carry out a wide range of multi-channel lap cladding, which proves the feasibility of the TiAl coating on the surface modification of the TC4 substrate. This study is of great significance for the practical application of the coating.