In order to study the influence of remelting power on the microstructure and properties of Inconel 718 nickel-based self-lubricating coating, laser cladding technology is adopted to prepare Inconel 718 cladding coating on 27SiMn steel plate, and three different laser power remelting cladding samples are selected. The surface morphology and metallographic structure of the cladding layer are observed by super depth of field microscope, the microhardness of the cladding layer is measured by microhardness tester, and the friction and wear properties of the cladding layer are tested and evaluated by pin-disk friction and wear testing machine. The results show that the grain size of the cladding layer is obviously refined after laser remelting. With the increase of remelting power, the grain size of the cladding layer decreases firstly and then increases. When the remelting power is 1 260 W, the grain size at the top of the cladding layer is the most uniform and fine. After remelting, the hardness of the cladding layer is greatly improved, and the hardness can be increased by 22% compared with that of the specimen without remelting. From the wear morphology, the wear mechanism of the sample is mainly abrasive wear, and the friction coefficient and wear weight loss of the sample are obviously reduced after remelting. The analysis of friction and wear test data shows that the specimen has the best wear resistance when the remelting power is 1 260 W.