To investigate the efficacy of laser point irradiation combined with salvia miltiorrhiza ligustrazine intraarticular administration in the treatment of knee osteoarthritis(KOA), 96 KOA patients were randomly divided into control group (n=48, salvia miltiorrhiza ligustrazine injection) and observation group (n=48, laser point irradiation combined with salvia miltiorrhiza ligustrazine intraarticular administration). The clinical efficacy, knee pain, knee function, knee range of motion and plasma levels of INTERleukin-1 β (IL-1β), C-reactive protein (CRP), cartilage oligomer matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) were compared between the two groups before and after treatment. Results showed as follows: the total effective rate of observation group (93.75%) was higher than that of control group (77.08%) (P<0.05). Compared with before treatment, VAS score, IL-1β, CRP, COMP and MMP-3 levels in 2 groups decreased after treatment (P<0.05), Lysholm score and knee motion increased (P<0.05), but the improvement of above indexes in observation group was better than that in control group (P<0.05). It is concluded that laser acupoint irradiation combined with salvia miltiorrhiza ligustrazine intra-articular intra-articular administration has satisfactory effect on knee osteoarthritis.