Long non-coding RNA (lncRNA) are a group of non-coding RNA that consist of more than 200 nucleotides. A re-view of the literature indicates that a large amount of lncRNA expression changes abnormally during the development of lung cancer. These lncRNA mainly affect the pathophysiological process of lung cancer by regulating the proliferation, apoptosis, migration, and autophagy of lung cancer cells. Recently, research on anti-lung cancer of traditional Chinese medicine targeting lncRNA is increasing. This article mainly reviews the abnormal expression of lncRNA and its mechanism of lncRNA action and summarizes the research progress of lung cancer treatment through traditional Chinese medicine with lncRNA as therapeutic tar-get, be expecting to provide new methods and new ideas for the treatment and research of lung cancer.