Sixty-four children with moderate and low myopia were randomly divided into the experimental group (orthokeratology combined with acupuncture) and the reference group (orthokeratology only). The changes in diopter and naked eye distant vision of the two groups after 2 months of treatment were observed and compared, and the occurrence of adverse reactions and the total treatment effectiveness were counted. Visual function and quality of life were evaluated by the Rapid Serial Visual Presentation (RSVP) and the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). The results showed that the diopter and naked eye far vision of the experimental group were significantly better than those of the reference group, the incidence of adverse reactions was significantly lower, and the total treatment efficiency was higher. In terms of RSVP score and NEI-VFQ-25 score, children in the experimental group were able to better improve visual function and quality of life.