Solid-state nanopore has emerged as a powerful singlemolecule method due to its labelfree and highthroughptu capabilities, and high temporal and spatial resolutionIt has been widely used in the detection of single molecules，including DNA, RNA, proteins,metal ions and others This review mainly focuses on the integrated system of plasmon resonance scattering spectroscopy and Solid-state nanopores, summarizes the research progress in this field, briefly discusses the princeples, fabrications and applications of these electrooptical nanopore, and further prospects the Raman scattering spectroscopy in Solid-state nanopores