In order to solve the problem that the output signal collected in the IEPE sensor data acquisition system fluctuates greatly and is not suitable for direct acquisition, a conditioning circuit for IEPE sensor data acquisition system is designed. In the design of conditioning circuit, the micro-power supply circuit, low-power programmable front-end signal conditioning circuit and high-precision analog-to-digital conversion circuit are used, and FPGA is applied to the whole in the design of IEPE sensor data acquisition system, the convenience of operation and the stability of work are enhanced. The test results show that the IEPE sensor data acquisition system has higher data acquisition accuracy and lower electric power loss value. The data acquisition system has strong practical feasibility.