In order to explore optical transmission characteristics between meridian tissue and non-meridian tissue before and after moxibustion, a self-made device is used to detect optical transmission characteristics with high sensitivity. The optical transport characteristic of pericardium meridian before and after moxibustion neiguan acupoint is reserched, optical transport characteristic of the non-meridian tissue before and after couterizing non-acupoint point is also researched which is 1 cm far away from neiguan acupoint. The optical transmission efficiency in pericardium meridian and non-meridian tissue both decrease after moxibustion, but there is a much more significant decrease in pericardium meridian than non-meridian tissue(P<0.05). These findings suggest that the optical transmission characteristics of pericardium meridian and non-meridian tissue are different, and pericardium meridian appears more sensitive to moxibustion. The results herein can offer beneficial reference in meridian studies and clinical application of moxibustion.