In order to improve the solubility and dissolution of insoluble drug aniracetam （ANI）， SBA-15 mesoporous silica carrier was prepared using P123 as template， and the pore-expanded L-SBA-15 carrier with enlarged pore size was obtained using 1，3，5-trimethylbenzene （TMB） as pore-expanding agent. ANI was loaded on two carriers， SBA-15 and L-SBA-15， to construct a drug delivery system based on SBA-15 mesoporous silica. The structure of carrier before and after drug loading was analyzed by SEM， TEM， FTIR， XRD and N₂ adsorption-desorption test. It is found that the pore sizes of SBA-15 and L-SBA-15 are 5.04 and 11.92 nm， and the drug loadings are 25.49% and 15.72%， respectively. Compare to the drug dissolution behavior in pH=1.2 and 6.8 dissolution media， it shows that both carriers can significantly improve the dissolution of ANI compared with ANI bulk drug， and the dissolution rate of ANI on L-SBA-15 carrier is slightly faster than that on SBA-15 carrier. This is related to the fact that ANI is highly dispersed in mesoporous materials and is physically adsorbed in mesoporous channels in an amorphous amorphous state， and larger mesopores are more conducive to the diffusion and dissolution of drugs. This study provides some certain experimental basis for improving the dissolution of insoluble drugs in order to increase the bioavailability of such drugs.