In order to solve the problem of spectrum fragmentation and inter-core crosstalk in space division multiplexed elastic optical networks (SDM-EON), a spectrum fragmentation and crosstalk-aware routing, core, and spectrum allocation (SFCRCSA) is proposed. In the routing stage, this algorithm comprehensively considers factors such as resource usage, crosstalk domain overlap, and spectrum fragmentation and selects candidate paths with low resource usage, low crosstalk, and fragmentation. In the core and spectrum allocation stages, the measurement factors of"crosstalk domain matching"and "crosstalk domain difference"are proposed. Based on this, a comprehensive measurement index of"crosstalk domain fragmentation"is presented to jointly consider crosstalk fragments and spectrum fragments, and the candidate spectrum block with the smallest value of crosstalk domain fragmentation is selected to establish lightpaths for arriving requests. The simulation results show that the proposed algorithm can reduce bandwidth blocking rates and improve the spectrum utilization.