In order to clean the oxide layer on the surface of the wire clamp of pure aluminum equipment, the technology of nanosecond pulsed laser cleaning the oxide layer on the surface of the wire clip of pure aluminum was studied. The influence of different power and spot overlap rate on cleaning effect and efficiency was studied by comparing experiments under different process parameters. Under the premise of high-efficiency laser cleaning, the laser cleaning process of oxide layer on the surface of wire clamp of pure aluminum was optimized by studying the influence of different repetition frequency and scanning times on the laser cleaning. Results show that: with the process setting of high power and 50% spot overlap rate, it has better and efficient cleaning effect. In the pre-foundation process, the surface would have more obvious cleaning effect if it is cleaned with the appropriate repetition frequency and scanning times. When the power is too high, spot overlap rate and scanning times will cause over surface cleaning.