As some aircrafts with large sizes, high accuracy or special structures need multi-instrument combination measurement networks to complete its digital measurement, this paper researched the optimal arrangement design of measurement networks. The traditional aircraft leveling theory was introduced firstly. A aircraft digital leveling algorithm was put forward, and its uncertainty model was established. Then, the effect of the accuracy of level benchmark points and the location of level points on the measuring accuracy was studied through the uncertainty analysis and error dependence simulation. Based on the measurement characteristics of the aircraft digital measurement network consisted of a laser radar and an iGPS, the optimal multi-station arrangement design of aircraft digital measurement network was put forward. Experimental results of aircraft leveling measurement show that the measurement accuracy of optimal multi-station arrangement design is 0.402 mm, which has improved by 20%. The optimal arrangement design is feasibility and effectiveness, and propsed analysis method provides reference basis for researching the multi-station arrangement design for aircraft digital measurement efficiencyth and accurately.