In order to achieve the laser cladding remanufacturing on engine crankshaft, the iron-based coating on 45# steel has been obtained by laser cladding. Properties of the cladding layers have been investigated. The morphology and microstructure of layers are observed by an optical microscope. The hardness of layers is tested by a Vickers hardness tester. It is observed that the layer and substrate has a good metallurgical bond. Average hardness of the cladding layer is 2~3 times of that of the substrate. In order to realize the laser cladding for the crankshaft rod journal while the crankshaft is rotating around the principal axis, the requirements to obtain the continuous and uniform cladding are proposed. Under the conditions, the trajectory of laser beam and rotating journal and their relative speed during laser cladding are deduced, and the feasibility of the model is verified by the experiment.