The damage effects and repair rules of pig skin tissue after different doses of 1 064 nm laser irradiation were ex-plored, so as to provide guidance for expanding the safe application of laser in clinical practice. This article used a fundamental mode fiber laser to output 1 064 nm continuous laser with different powers. Live pig skin was irradiated at multiple spots one time by using a grid-array method. The skin injury reaction was observed and its incidence was calculated immediately after la-ser irradiation from low to high doses. The weighted probit method was used to calculate the damage threshold ED50. The heal-ing and pathological changes after laser-induced skin injury were observed dynamically within 6 h and for 28 d after laser irra-diation. With the increase of irradiation dose, laser-induced skin injuries ranging from mild to severe appeared erythema, white spot and burnt spot in turn. When the dose was lower than 70.0 J/cm2, a reversible erythema predominantly occurred. When the dose was 192.2 J/cm2, a burnt spot predominantly occurred with an incidence of about 51.4 %. However, the incidence of burnt