In order to achieve electrowetting real-time display, a display driving system, consisting of a DVI video codec system and FPGA timing control system, is designed. DVI video codec system is responsible for obtaining signal sources and for image coding and decoding. FPGA is responsible for buffering and processing of video data and for controlling electrowetting driving waveforms. This paper also proposes an improved multi-grayscales dy-namic symmetrical driving waveform, which improves the ink-splitting phenomenon and suppresses the charge-trapping phenomenon while increasing the gray level. The results show that the driving system successfully improves the problems of oil-splitting and charge-trapping, and drives the 1024×768 resolution electrowetting display to play video in real time following the computer. The frame rate of the video reaches 60 frames/second, and the highest gray level of the pixel reaches 15. These properties meet the requirements for dynamic display of the electrowetting paper.