Micro-/nanomotors(MNMs)can perform autonomous motions, and have potential revolutionary applications in fields such as biomedicines, micro-nanofabrication and environmental detection and remediation. After briefly introducing the basic concept, propulsion mechanisms, construction strategy and research status of micro-nanomotors, this paper will focus on biocompatible Mg-based micromotors, which have firstly been developed in our research group, and free swimming functionalized sperm micromotors with intrinsic chemotactic motile behavior in biological and environmental media. Then, the light-controlled MNMs of various structures including Janus, single-layered tubular and isotropic structures are demonstrated. These intriguing properties offer them ample opportunities to act as motile platform to manipulate and assemble micro-/nanocargoes in highly sophisticated ways. In the end, the prospects about MNMs operating in living bodies, which should have powerful thrusts, specific sensing, external tracking and self-targeting in physiological environment like blood vessels are also presented.